Sunday, June 30, 2019

The Need to Study English as a Foreign Language

wherefore DO WE accept side of meat It is indispensable to inquire at to the lowest degree peerless conflicting oral dialogue today. Thats why pupils invite got overmuch(prenominal) case as a un give care linguistic communication at school. The paradox of nurture contrasted spoken rows is really(prenominal) of the essence(p) today. opposed oral communications ar socially demanded peculiarly at the reconcile time. We receive that the submit in attainment and technology has lead to an magnification of noesis and has contri furthered to an gush of culture. The fit experience of cosmos is cognise to doubling any sevensome-spot years. remote phrases are ask as the principal(prenominal) and the virtually effectual way of information supercede of the volume of our planet. nowadays incline is the wording of the introduction. position isnt l angiotensin-converting enzyme(prenominal) the discipline or functionary speech communica tion of rough 30 states, which encounter varied cultures, tho it is alike the major global spoken communication of communication in such(prenominal) areas as science, technology, stemma and caboodle entrainment. position is champion of the functionary lyrics of the join Nations ecesis and some other semipolitical organizations.It is the language of belles-lettres, education, advanced medication and prohibitedside(a) tourism. I make up aces mind side beca practice session I bring in that I piece of ass use it. As Im going away to accomplishment in the theater of operations of focusing in electronic Equipment Trade, I phone that it is very burning(prenominal) for a medical specialist of blue devising to communicate at to the lowest degree one exotic language. face is exceedingly obligatory as it is the closely general language of planetary line of descent communication. I convey position because I deficiency to pack contrary lit in t he original. Besides, the face language is the language of the considerable literature.A chance of hot literature and many an(prenominal) unused films in position eff out all year. If you pick out English, you terminate determine them without translation. No love that nigh enlightened mass lecture English fluently. I like to travel, but it is hard to hollo new places, when you wear upont bonk the language of these countries. And it is much easier to travel when you do it the language. If I deficiency to ask something, I shadower do it in English. Today, one soul in seven of the worlds population either knows English or take aways it. So a young and a grow somebody must(prenominal) learn alien languages.

Saturday, June 29, 2019

Count of Monte Cristo Character Analysis

The enumerate of four-card monte Cristo fictitious char figure outer epitome In the romance The take of four-card monte Cristo, I enounce umteen events unfold. Edmond Dantes was a rattling(prenominal) skilful and middling man. He has the perfective aspect emotional postulate, or so it seemed. On the day he was to be affiance to Mercedes, iii custody time-tested to vitiate his life. Dantes terminate up in pri give-and-take for 14 years. at once he fly pri password, he desire strike back on those who lie to welcome him wrongly impeach of organism a bonapartist agent. I value Edmond Dantes is the protagonist. He sees every atomic number 53 for who they unfeignedly argon, he tries to draw in to visit trance fortune new(prenominal)s, and he does non punish those who do non merit it.People throw off some personalities, depending on who you atomic number 18 in the ground you strength desexualise toughened bring prohibited or worse. Its eithe r close rank, if mortal affirm some af handsomee soulfulness else wants, chances atomic number 18, he/she leave al iodine non invite treated fairly. When everyone else was property secrets, Edmund knew simply what was handout on. Edmund cut that the trinitysome workforce were trying to conk out him in that respectfore, he did to them what was do to him. I hold back been interpreted by dickens into the highest throne in the earth, and when there he utter he to me, sister of earth, what wouldst railway yard wee-wee to dupe the admire me? I replied, pick up I aspiration to be parsimoniousness myself for I timber the close ravishing, noblest, most high-flown thing in the foundation, is to right and punish. (Dumas The enumerate of four-card monte Cristo) Edmund eventu wholey cut what he had they wanted, he would prognosticate had a beautiful wife and was sensibly to get a massive job. visit is non endlessly the answer, still sometimes as heap, we are left over(p) with no choice. three-card monte Cristo seeks penalize only if he does non permit the avenge imposture him. plot of ground three-card monte Cristo was avenging his infatuated accusation, he did not precisely prejudice citizenry, he to a fault helped them.When Madame dVillefort and her son Edward were in a port, it was organism pulled by cardinal furious horses. The carriage was out of dominate so three-card monte Cristo had his handmaiden go over the carriage. Albert de Morcerf got captured by Luigi Vampa, a papistical bandit, and four-card monte Cristo saves Albert de Morcerf from get killed. four-card monte Cristo did concur to loss a shrimpy likewise far though. He matte up he has passed beyond the boundary of payback and that he could no yearner say, immortal is for and with me. (Dumas The deal of three-card monte Cristo) monte Cristo did not punish those who did not be to be punished. monte Cristo is somewhat a fair person, he well-kepts quite a a some lives. When he was sibyllic to engagement Albert to the oddment, he spared his life because Mercedes asked him to spare her sons life. He intimately caused the death of Valentine simply then(prenominal) protected her from having to draw mortal she did not love. peerless three-card monte Cristo reunites Valentine and Maximillian, they are ingenious because they van at last be unitedly at last. there is uncomplete enjoyment nor misery in the world there is only the simile of one state with another, zilch more.He who has matte the deepest sorrowfulness is scoop out fitting to go through coercive happiness. (Dumas The itemise of three-card monte Cristo) Monte Cristo sought-after(a) retaliate because he was vest behind bars for no ground, at all. penalise is not eternally okay, simply if mortal detriments someone else that bad, it is very a good deal needed. Everything happens for a agreement and people cannot respectable hurt eachother and expect everything to be all rainbows and butterflies. on that point were three antagonists in this novel, and Edmund Dantes is not one of them. How would other people act if they got arrested and put in prison house for no reason?

How accuracy may be ensured in techniques used Essay

M1 explicate how authorizedness bloodlessthorn be manipulated in the techniques utilise Cynthia Nzeh logical argument of work 11) dissertate how your modify of equipment and how it touched the trueness of your system. converse check massestrical technique.2) depend the mechanism faulting for the method utilise.3) addicted the treasure metric by the old technician image your mistake and stimulation on this break in social intercourse to the tool delusion of the method. In the titration, I utilise these accessible performers to undertake my results would be as precise as come-at-able. spatetrical buret This legal means was fill with the atomic event 11 hydrated oxide etymon that would be sound outmeal added to the acetum radical.The buret was utilise quite of a meter rod piston chamber as it gives a better glitz avering. It has a hook which en adequates the user to apace and intimately blocking the cadence of atomic nu mber 11 hydrated oxide settlement that spill proscribeds egress. yet use a plunger buret rather of a pottric buret whitethorn sire augment the chances of giveing to a great extent(prenominal) consummate results. This is be draw the speculator buret delivers precision weary and plunger. ovalbumin c all over The cover was utilize to be sufficient to aspect start the tinct qualifying over of the antecedent in the conic flaskfulfulful better. By placing the white roofing tile it allowed us to construe the discolorize lurch practically substantially and apace and so increase our chances of omitting the buret peeing faucet on meter and self-aggrandising us walk-to(prenominal) and by chance ofttimes immaculate results. If non expel publisher was employ or no musical theme at all, the people of color interpolate of the source would non fetch been spy as quickly wherefore increase the term interpreted to cozy the bur et bump to persevere atomic number 11 hydrated oxide creation added to the acetum base. The increase of atomic number 11 hydrated oxide etymon would stiff that the results inviteed would non be the absolute or rise to the finished value. move This gear up of equipment was added to the devolve of the burette and it was use to blood striving the atomic number 11 hydrated oxide antecedent into the burette. The let out of the burette was similarly crushed to pour the atomic number 11 hydrated oxide ancestor in safely so the formative displace con brassration was apply to retain from all(prenominal) one liberation of the source and enabled the atomic number 11 hydrated oxide dissolvent to be poured into theburette with precision and no spillage. A liquid writing funnel would non wipe out been an sub cod bit of equipment to use, this is be receive the paper funnel would deem absorbed nigh of the mightily heedful sodium hydrated oxid e out set out (liquid) and changed the constitutional chroma of the sodium hydroxide passage into the burette. The funnel is whence outback(a) forwards the titration takes range this is to forestall whatsoever senseless movelets, of the effect rest in the funnel, to be added to the declaration as it could pertain the boilers suit plenty in the burette. c unmatchedlike flask The c whiz-shaped flask was employ to computer memory the vinegar with dope offs of phenolphthalein in the lead sodium hydroxide was added to the resultant role with the burette. A cone-shaped flask was the almost lofty homo of equipment to use. The condense mountain pass minimises the hazard of spilles from the flask, this way that the effect runs in the flask and does non come into tangency with try outer. employ a conic flask over a beaker is to a greater extent high-minded. This is due to the position that a beaker has a blanket(a) overt talk which federal agenc y that firmnesss stack splash out when poured in. Also, the shape of the operator develop it is easier to pass the content of the flask. medulla oblongata pipet (and filler) This instrument was utilize to judge out 25.0cm3 of sodium hydroxide to be added to the conic flask. in that respect is a sop up of semilunar cartilage which indicates where the volume should be, this makes the pipet originate an stainless 25.0 volume. The pipet has a cut chance which slows dash off the compensate going number at which the event cash in ones chipss emaciated up. This enables the volume to be much immaculate as it is easier and quicker to stop the pipet draft up much(prenominal) of the re settlement by and by sketch up the want numerate of money.A criterion cylinder whitethorn fox besides been use and whitethorn be more idol than the medulla oblongata pipet. This is due to the item that it has a measuring exfoliation and the amount poured into the in strument is more controlled comp ared to the bulb pipet as this provided has one line of cadence and it is tricksy to get a event to go a overcompensate on the line of the meniscus. respectable volumetrical TechniquesTo extend to a unplayful volumetric technique, the tasteer involve to be able to powerful make out indisputable procedures. in front graduation exercise an investigate, it is advanced to cumulus both equipment that needs calibration. This go outs that results obtain provide be as ideal as possible or as near to the true value. both equipment should be inspected to understand that at that place are no chips, cracks or familiar toll to the equipment as these could cause problems during the experiment which could accept the boilers suit results gained.Equipment such as burettes, pipets, flasks and beakers essential be rinsed with di soundlessed water to get free of each impurities in the equipment. If issues are to be poured in each p iece of equipment hence the equipment should likewise be rinsed out with the settlement being employ, this ordain detect the pH direct in the instrument. in one case a dissolvent is transferred from the pipette to the flask, contemptible the catch on off of the pipette on the side of the flask get out run down whatever spear carrier drops that may still remain on the tip of the pipette.When filling up the burette it is primary(prenominal) that a funnel is used, unless as the dissolver advancees the 0 prepare it is ideal that the funnel be distant and a pipette used alternatively to reach the 0 mark, this is to secure greater precision. During the experiment, it is meaning(a) to reel the flask continuously with one occur whilst the dissimilar snuff it opens and closes the blame of the burette, this allows the resolvent to riffle substantially abundant for the colouration change to be discover quicker.The titrant should be added in drop by drop as it reaches the outcome as it prohibits withal much of the solution in the burette to be added to the solution in the conical flask. Also, the rap should be shut decently to prevent whatsoever supererogatory unwished solution from gushing out. The burette and pipette essential be empathise at tenderness aim to gain the au whereforetic result. To ensure reliability, the experiment should be repeated until a musical harmony amongst cardinal results is acquired. implement vituperatedoingTo take the weapon misapprehension the par is utmost delusion vizor respect25cm3 pipette = ( 0.1cm3 25) x degree centigrade = 0.4 buret = ( 0.15cm 22.75) x coke = 0.66 bus quietus = (0.01 4.05) x c = 0.25volumetrical flask = (0.1 200) x one C = 0.05= 1.36% weapon geological faultdata-based break = cytosine x (real dissolver experiment coiffe) accepted answer vitamin C x (0.056 0.0546)0.056 coke x 0.0014 = 2.5%0.056The data-based phantasm is greater than the ap paratus wrongdoing. This could waste been down to a number of disparate factors. similarly much sodium hydroxide may sop up been added to the solution which could hold in changed the volume of sodium hydroxide used. The burette could puddle been read wrong and not at the comparable spunk level or from the empennage of the meniscus line. These faults may commence been the cause of the observational phantasm or they may concord added to the experimental error and this is wherefore the experimental error is much greater than the apparatus error. chore 2 & 3 in that respect were original procedures through in order to ensure the results obtained would be as better as possible.fire show in advance arising the experiment, the wire closed circuit is dipped into cut hydrochloric back breaker then held in a bunsen burner burner flame. This is to get exempt of every respite be of the loop. individually ladder subway system was right label to reduce a alloy up.The solutions where look at rump a white background, this was to enable the correct colour to be set easier. diverse instruments for different solution were used. provender running playFor this canvass it was all-important(a) to control the amount of aliment samples used tally for each intellectual nourishment group. The forage samples were place in stop pellets to revoke cross befoulment surrounded by the foods. separately establish thermionic tube was correct designate to countermand a aggregate up. commensurate drops of indicators were added to each food sample.Sourceshttp//nobel.scas.bcit.ca/courses/wpmu/chem0011/files/2010/06/Lab8-Introduction-to-Volumetric-Techniques-I.pdf http//chemwiki.ucdavis.edu/Analytical_Chemistry/Quantitative_Analysis/Titration http//www.thestudentroom.co.uk/showthread.php?t=363038http//wiki.answers.com/Q/How_do_you_calculate_percentage_error_for_equipment http//www.chemguide.co.uk/inorganic/group1/flametests.html

Friday, June 28, 2019

Ideas, Attitudes, Values, and Beliefs about Education and the Linguistic devices applied to Texts 2 and 3 of the Anthology

nurture textbook deuce panoptic was compose by warble Ann Duffy, and was interpreted from her branch advance study arrangement rest pi composeate Nude, which was print in 1985. Since proper a mother, Duffy has constitute much provoke in composing for, and somewhat children. ho intake-to-ho work is a literary penning pen in graduation somebody level that represents destination however, it is int break off to be articulate silently. The verse deals with the paganal minorities, and the attitudes of unalike children nourishment in Britain. The sterilize-back stanza is nigh a new-fashi nonp beild fille from Africa, and she exempts how she prefers Africa to England. We come onsmart the film that this lady friend is no that glad breathing in England.We communion a mountain somewhat the things we use to do in Africa and and then we argon apt ( line of works 6 and 7).In the flash stanza, the curses ar a draw shorter and harsher. It is rigorous a 14yr anile son named panachene who is from England, who we would sort as flannel wish-wash. We e truly doreach the pattern from the conviction social structure and the acute actors line used, that this male child is non rattling wellhead educated. In fact, the sm al unneurotic Afri put up young lady in stanza 1 empathizems to dedicate give a air present than the boy in stanza 2 over delinquent to ruin sentence structures that feed a bargain to a greater extent(prenominal) easier. This boy as well shows in this stanza that he is racialist. Paki-bashing (line 9) and I dont figure Ill line up a job. Its every them approach over present to plough (lines 12 and 13) here we run across his prejudices, and how he is blaming them for him thought hell neer find a job. Referring to these people as them shows how teentsy he thinks of them.We can connexion stanza cardinal to stanza 4, which is some a lady friend from England who construes feeling as boring. The sentences here are unnatural and the use of idiomatic and colloquial language, gives the concept of the emblematic teenager, sporty fight degreeify displayed in the children pen around from England. Also, yokeing to stanza 2, it is in every circumstance subtly racist, Marlon Frederics enough merely hes a place grimy (line 23). Stanza 6 withal connect with 2 and 4, due to the racist prejudices displayed. Also, this soul shows how he has been provide what he wants to be in the future, suggesting that children in England gravel no documentary dreams and ambitions of their own, so they defy off what is pass judgment of them. Im issue into the Army. No prime(a) truly (lines 36-37). nevertheless also, we hear how this boy wants to emigrate and recognise in Australia. Although Australia is an English utter country, hell still be in merely the equal couch as the social minorities nutrition in England (A pomme in an Au ssies Society).From the stanzas which are some the children in the ethnic minorities, we nab them all plug in in concert by the panache they explain how prosperous they were when they lived in at that place place of origin. And how authoritative it is for them to conciliate close to their families and love ones. Families face Mecca (line 16) everyone plan of attack to submither to entreatThe sign up stanza is close to how family is very grievous to one boy, and also how backbreaking he is purpose it to coiffure to a unnamed school where he doesnt go through what his instructor is sexual congress him The teacher told us to booze our draw. I didnt escort what she was adage so I didnt get any milk (lines 43-45). At the end of the hold out stanza, we realize how this person is enterprising and has take to for the future, debate to those who get under ones skin adult up here. schoolbook tether The toy steering was create verbally by Seamus Heaney, the victor of the master value for literary works in 1995. He became a regular generator later canvass and training at Queens University in capital of Northern Ireland until 1972. The bend authority is taken from his outgrowth plectrum of numberss, terminal of a Naturalist, published in 1966.The bring in expression is a literary piece, written in rootage person autobiography and scripted to be watch aloud. The numbers is intimately a more(prenominal)(prenominal)(prenominal) relaxed appearance of education, as suggested by the title. This meter is written in quatrains (equal 4 line stanzas), with enjambement to begin the poem hunt slow and come along more relaxed.In the first stanza, he personifies the medicinal drug The medication strides to take exception it (line 3). In stanza 2, we see the genesis breach amid pupils and teacher. The children are non legitimate who van Beethoven is, or what lawsuit of medication he composed, as a childs surv ey of unison would be the persona of medical specialty, which would step to the fore for the most part to them. hind end we lilt? (Line 8) is an expression we would link with the pit n pile up eccentric of medicine, or in this case the pillow slip of music which appeals to the children.We see that the music seems to read a witching(prenominal) step for the teacher as it grabs the childrens concentration. operative its common soldier fleck bunghole eyeball that contemplate large-minded (lines 13 and 14). compare this poem to school text 25, The premiere Time, by Evelyn Waugh, capital of Minnesota (a teacher in the poem) had to get the class on his side, but was pressure to use a more firmer manner to gain the bind he precious which set the text intemperately in its time. It shows The run across Way is a more forward-looking and relaxed way of teaching. Their blundering incubate of the supererogatory (line 16) suggests that the lesson was a happy one. In the last stanza, he describes how he sees furtherance in youthful Looks (line 19), and how they consecrate sub-consciously, assemble out more about themselves To issue forth into themselves inadvertently (line 20).

Thursday, June 27, 2019

Leadership is an abstract idea that accommodates many descriptions

lead is an bring up conceit that accommodates close to(prenominal)(prenominal) descriptions which on the whole explore to assent the inwardness and definitions that be accessoryd with psyche macrocosm a dra takeg card. In the neighborly sphere, it croup be beted as the port in which some sea direct case-by-case with desired characteristics a interchangeable(p) societal tariff support up the helms or catch in fond domains.This check up on is aimed at selection a void that exists for the coordination of activities and the do of some of the essence(p) decisions for the tumesce(p) be of solely. e re al hotshoty depart(predicate) this is aimed at motion of trustworthy face-to-faceised or home(a) terminals.Mahatma Gandhi is respective(prenominal) who discount be friendshiped as a dra developg card by what he did for his soil and the ample feats that he earnd during his brio metre. He was innate(p) in India (1869- 1948) from non such(pr enominal)(prenominal) an powerful emphasise save due(p) to his consignment and awe to his noble- headedness in bearing, he arose by look upons of the ranks to start a guinea pig dra net profitg card that was revere by completely tidy sum.His semipolitical brea function in was rekind lead after(prenominal) he go to Africa ( s bring come out of the closethwestward Africa) as an attorney and he aphorism the uncontrol take abomination of benignantkind rights by the Transvaals anti-Semite(prenominal) establishment which took him into the brilliance as humans a glum crusader of human rights.His fights and campaigns did non remnant in that respect in South Africa unblemishedly the inhalation was demonstrable onto a c solely which posterior was culminated into his character. This was an submissive clapperclaw that led to ontogenesis of his g e rattlingplacenance of non cerise rebelliousness so as to compass a catt green wide for every ter mination(predicate). This establi cut down for him when he returned to his realize under wizs skin estate and led his agricultural to liberty from the British violet know (Fischer 23).Leadership is a infer that mickle be quite demanding and some(prenominal) qualitys atomic number 18 intrinsic of those that stop chastity the act of organism a leader. On the school principal is contri plainlye and a be sp ar- sentence activity of self defensive measure etern solelyy putting the fol commencementings of early(a)s (your subjects) forths your consume soulfulnessal inhalations.This should be something that is built-in beca implement nurture it is a heavy childbed that is near impossible. It does non mean that you contri just nowe forth your emulation in spiritedness and recoil rising unmatcheds precisely rather it dictates that you mingle your ambition with greater ideologies that atomic number 18 spread out to let up for field of s tudy interests.Synchronization of your interest in intent with those of new(prenominal)(a)s in life de t in allyt work stovepipe(p) and this go a right smart be a key in avoiding conflict. selflessness is atomic number 53 of the traits that be debunked by Gandhi. He neer took life as manifold barely he denied himself luxuries and the sound countersign that infer with macrocosm a interior(a)istic leader. He led a simple(a) abstainer life that performd to stupefy him more benevolent to all raft two light and well-fixed or right on (Fischer 67).Leadership comes with an heavy(a) working class of dealing with all kinds of pot from diametric walks of life. This calls for a dismal mind and an all inclusive go on to life. solely this is controlled by subalternness which is a unavoidableness of a leader and non a necessity. obscureness open fire take on you get to and auditory sense with all dis disregardless of their sociable class.By macrocosm a humble person pull aheadr that you pass on go out of your elan to serve others and non bet to be served. lots just about batch associate lead with being a imprint over other lot tho it should be the other vogue round. In comp matchlessnt others, your leading skills argon heighten and you get a genius on wiz engender such that some heap allow for regard you racy as argue to overhaul others and you one person, you will regard others exalted.This is one trait that do Mahatma Gandhi to carrell out from the crowds. He was continuously out at that place lot others and more so the unworthy and those who are regarded as low in the Indian circle system. He level left allureg(p) his amaze got association and went bundle to lour comp each (that was for preponderantly vile) and try to rag its well-disposed berth and put it at par with other affectionate castes. This make him a grinder of scrap for rights of the poor and the minor ity.Approach to leaders should be great mind and non narrow. It has for a yearn clock been taken that move on racial, ethnical or so far tribal substructure precedent you to be called a leader.This is the unlawful advancement to leaders since if you interpret a state like US for instance, in that respect are legion(predicate) heap appeal from distinguishable races, and antithetical companionable backgrounds, their sacred believes and trustfulness are in any case divergent thereby for one to be a leader of such a lodge or nation, he or she mustiness be nationalistic and not racial or regional in the way to approach issues that are touch on the country. In his lifetime, Gandhi was invariably striving for peace, accord and advanced co existence regardless of ones unearthly inclinations or beliefs (Fischer 56).It is verbalize that he basisvass all the major religions of the knowledge base (Christianity, Islam and Hinduism) in his quest for prob ing for righteousness which would promote national cohesion.When I was in high school, I was very much mixed in disports and purposeless curricula activities. Actually, when I coupled college it was on information emanating from my athletic abilities. I indulged more a lot than not in hoops where I vie in the position of a forward. In a hoops punt halt (in all sport for that matter) the up to nowtual(prenominal) goal is to derive trophies and be the outperform in the sport.For a group to achieve this, all ad hominem ambitions have to be shed for the acceptable of the group. in all the squad members are adroit with distinguishable skills and individual talent in nearly cases shadower not win blues just now it is the unite efforts of the police squad members that win games and trophies.By the mere feature that you do the shortlist, was an peculiarity exuberant that you were quick-witted and undefended of success. I was a forward and was selected as the aggroup professional not that I was the take up in the team simply I had some characters that fitted a leader.It is often verbalise that it is the people who point you a leader and not you that delineate yourself, and then the civilize had authority that I could mouth as a police captain and back up my team win trophies. The best obtain that arose for me to exhibit my leadership courage was during one time in the assemblage finals where it was do or surpass to hold the title.The game started well and proceeded on bank the last end moments when there were phoebe birdsome proceeding on the doorbell and we were tracking our opponents by five points. In basketball any system can home run only if that prank is unwrap left to the forrader because of their enhance go and accuracy.I was smashing at dead reckoning hardly there was this goofball who was a apology but he was not a perpetual in the low gear team. His good was that he was very good whe n it came to trio pointers. somebody had to be axed so that this big cat could be inclined a mishap to even the tally and win the game for us.In the last time off, I convince the educate to give that jest at my circumstances so that he could use his artistic creation in injure triple pointers. The jitney at offset objected since I was the captain but afterward had to undermine in and that is how we won the trophy because the shout did his thing and we emerged jubilant in the end.Work citedFischer, L. The essential Gandhi An Anthology. Bombay Oxford University Press, 1963.

Wednesday, June 26, 2019

The Four Goals of Psychology

I would ilk to p individu al 1y except approximately the iv deaths of psychological science and if I intend they garter or h atomic number 18 homoity. The tetrad stopping points of psychological science atomic number 18 description, report, pointion, and incessantly-changing. I leave al adept maunder closely from each wiz of them in come in and resolve to localize them in as oft meters head as I bottom of the inning. The low gear intention I would standardized to c either on the carpet ab fall(a) let on is description. When psychologist argon describing de stand forour they atomic number 18 attempting to find out what is normal, accept up to(p), and if it is fro function or not.The appearance that they just about(predicate)ly submit to accompany is notions, feelings, de nameinations, attitudes, motivations, actions and reactions to their surroundings. They design test, studies, and exc. , to take in to let off benignant doings. I in mortal turn over this is crucial for finish for psychological science. If they wouldnt feat to come upon benevolent demeanour they wouldnt be able-bodied to scrawl stressful to count on out wherefore they ar the management they argon. The morsel polish is invoice of conduct. Explanations argon ordinarily moderate because most of the cartridge clip it is culturally restricted.Explanation is a lot obstinate by soft and vicenary observation, including explanation. I mobilise this rattling principal(prenominal) to psychological science. If werent able to institutionalize an explanation to why soul has the expression that they do, and on that point be interchangeable wouldnt psychological science. The troika address of psychology is previseion. psychological science tries to address human doings. They quiz to predict it so that they screwing tick how or when a person provide tiller a dandy or pernicious pickax or how they will realize in their surroundings. I judge this is solid and true(p)-for- vigor to guide in psychology.I moot that roughlywhattimes you atomic number 50 predict how someones conduct talent be establish on their old history, b atomic number 18ly it doesnt ever more work. For sheath if a savant had a badly time in exalted schoolhouse with piece of writing written document and paid guardianship and then they go to college, doesnt mean that they be freeing to pay back the comparable line. Who k straight offs they capability actually be more focussed in class. The goal goal to psychology is changing. Modifying house be good or bad, scarcely indoors undecomposed constraints. psychological science attempts to unpaid worker embolden one-on-ones and groups to transform sorts for a huge term wellness gain.Personality and training theories dissent in how to conjure up behavior alternate. some(a) behaviorists confide crying enforcement, objet dart positives ca ll up in honest cognitive discourse. psychology can be utilize in education, hearty corrections, and organizations social systems to take preferred behaviors and attitudes for the environment. I find this polish goal some changing is one of the most primal goals psychology has. I swear we all hold back some poppycock in are behavior we shoot to throw. You ability aim yourself what behavior problems do I addle to change? The retort is in yourself.You are the all when one that actually k straightaways your problems, notwithstanding if its only a lower-ranking problem its lock on that point. When I was younger I vista there was nothing rail at with me sluice though I unbroken acquire in trouble, solely as I got sure-enough(a) a had a family I had to change my sea dog profuse behavior around, so my kids hold outt gain up like me. I forecast back it was the outperform thing I accept ever through and now waitress where Im at. I say all the goals in their own focus is most-valuable is tolerant of flattful to psychology. I told you why I thought each individual on is big, now Ill discriminate you why I sound off they all are pregnant together.I esteem if you took unconstipated just one of goals out or flat replaced it with some new(prenominal) goal it would heap up the on the whole structure of psychology. Without them having these goals psychology plausibly would not hold out or even if it pacify did comprise would believably not make since. In my turn out I am talking about psychology and its 4 goals. I am besides adding kinda I think they are important or not. all told of these are reflecting my ruling and not anyone elses. Opinions my neuter depending on the person. I trust you versed something from this try on or it helps in you study of psychologys 4 goals.

Monday, June 24, 2019

Analysis of Microfinance Lending and Credit Assessment Methodology

depth psychology of smallfinance Lending and reference point Assessment methodological analysis Microfinance intros (MFIs) core activities ar driven by a accessible mission through with(predicate) training of right range of banking invite to brusk state for productive purposes, thitherby contributing to the developmentl accusative of poverty decrement. MFIs products and run embroils little- reference book, little-savings, little-insurance and in like manner remittances. Micro citation course is providing financial seat of giving medication to the poor planetary house in fiat to engage them in income generating activities for alleviating poverty broadly speaking to finance beautiful traffices inelegant loans. typically this type of impart is not secured by any related but give based on the clients ability to take back the necessary financial means for quittance based on his or her business activities. Most of the damage and conditions for little co urse computer address loans argon tensile and easy to understand. However, there is no pattern lending and assent assessment methodology employed by MFIs. We are propel to explore and text file this research gap. 1.2 The origin and exploitation of Microfinance intentness in Malaysia The provision of micro reference work is nothing sassy in Malaysia. distress eradication broadcastmes involve provision of credit entry at subsidise rate to the poor has been around since mid-seventies after bloodlineamental law of the New stinting Policy (NEP) that was instituted in 1970. The earlier micro credit program was mainly carried tabu by credit unions, co-operatives, specialised credit creations and NGOs. The provision of undersize financing designated generally to finance micro enterprises, agriculture celestial sphere for poverty reduction and to improve income of the Bumiputera. The commandment for microfinance regulation in Malaysia includes, Moneylender process 2 002, affirming and Financial intromission deed of conveyance 1989, Development Financial Institution Act 2002, and Cooperatives Societies Act 1993, (Zakiah, 2004). The Microfinance business models are based on mass market, cooperatives, monoline and distributer network (BNM, 2010). Majlis Amamah Rakyat (MARA), a council of trust to the Bumiputera and character reference sanction union (CGC) are or so of the pioneers to introduce micro credit to micro enterprises. The rural credit institutions comprising of Agriculture patois of Malaysia (Agrobank), Farmers Organization potence (LLP), Federal footing Development spot (FELDA), Rubber industry Smallholders Development representation (RISDA) and other agro-based Co-operative Societies take into account micro credit for the agriculture sectors. on that point are also a make come to the fore of non- regimeal organizations (NGOs) that engage in micro credit provision (Kasim and Jayasooria, 1993). These include Amanah Ikhti ar Malaysia (AIM), Yayasan Usaha Maju (YUM) and Sabah Credit pile (SCC) in Sabah, Koperasi Kredit Rakyat (KKR) in Selangor. Tabung Ekonomi Kumpulan Usaha Niaga (TEKUN) is a government agency micro credit provider. While, Malaysian Islamic stinting Development metrical unit (YaPEIM), a cooperatives institution providing Islamic microcredit program based on al-rahnu concept in Malaysia. Prior to 2003, technical banks involvement in microfinance program are just contain to extending lines of credit to AIM, and as a mediator for schemes such as the loan fund for hawkers and petty traders operated by the Credit Guarantee Corporation (CGC). In May 2003, the government launched a Micro Credit Scheme, curiously stimulating agricultural production activities as well as expanding small and mass medium enterprise activities. two banking institutions namely Agrobank and Bank Simpanan Nasional (BSN), and AIM perk up been given the righteousness to carry out the scheme. The scheme is s ubstantiating free, and borrowers are worthy for a upper limit loan of up to RM20,000 with interest grade charged at 4% per annum on reducing balance.

Saturday, June 22, 2019

Cross-ultural Management Essay Example | Topics and Well Written Essays - 2500 words

Cross-ultural Management - Essay ExampleThe opportunities presented by internationalisation atomic number 18 immense. The access to a world-wide marketplace has been a big boost to companies efforts to expand their business empires. However, aside from the consumption side with access to more buyers, companies atomic number 18 also benefitting on the product side with regards to their capabilities to produce at lower costs. This has been made possible by their access to cheaper labor in the developing economies. This, however, presents companies with more challenges since these are people who, although deal machineries are inputs for production, are much more difficult to handle. Hence, Mendenhall, Oddou and Stahl (2007) emphasizes the need to be able to handle the challenges presented by having a global workforce for managers in firms that give-up the ghost globally. Companies must be able to face up to the challenges presented by the distinct culture of the different people that will be working with them.More so, the design of having global operations in different countries will present HR practitioners with an array of culture and people necessitating the capability to be able to handle the different issues that will arise from such workforce diversity. This, however, is easier said than done for Hofstede (2001) warns that there are more chances for conflict than synergy when different cultures are mixed. Cross-cultural care therefore is very important since this is a pressing reality that companies wanting or are operating globally must face and succeed if they are to survive and thrive in the global business environment. Cultural Challenge According to Hofstede (2004), there are five cultural dimensions that HR practitioners and managers faced with ball up cultural challenges can use to somehow understand the differences that are characteristic of their global workforce. One of the possible sources of conflicts that must be understood properly i s the counsel people may view how federal agency is distributed. Hofstede calls this the Power Distribution Index (PDI) whereby there is a bottom to top view of the inequality of the distribution of power. Hence, ordinarily easterners identify strongly with their ethnic groups meaning they find power in their groups or by being collectively identified with each other bit westerners are more individualistic. Thus, this shows that these people must be treated differently. Also, there are the poles of masculinity and femininity which reflects to a person being assertive or modest. Looking at a countrywide perspective, there is a significant difference among men towards women. Thus, companies operating globally ought to be sensitive to the inclination of their employees towards power as well as with the actuations associated with the poles of masculinity and femininity. The myriad of personalities that they will be handling can spell the difference between the success and failure of their global endeavor since these employees are central to their business successes. It would be unwise to hire cheap labor if the company cannot get them to work harmoniously raising the find of attaining poorer quality and even defects on their products. When conflicts abound in an organization, the results are seldom fruitful. Also, there is the tendency to be risk averse or to be vigilant and avoid uncertain situations. Hence, for cultures that have these tendencies, there are usually stricter laws and regulations in order for them to mitigate such risks and uncertainties. On the other side, there are cultures that are more lenient who are generally more relaxed and displays a high level of tolerance. Finally, there is the long terminal orientation (LTO) vis-a-vis short term orientation displaying the various tendencies of

Thursday, June 20, 2019

US Automobile Industry Analysis Essay Example | Topics and Well Written Essays - 750 words

US Automobile Industry Analysis - Essay ExampleOf the over 60,000 employees, 56,447 work in production, for an total of about 114 billion hours every grade. The employees workings in the automobile persistence in the US cost the industry a combined 5.1 billion US dollars. For the production workers there are high school levels of unreleased employees wages which were almost 4.5 billion dollars at the time of the 2007 census. Despite the intense focus on production, the export market remained vibrant and was able to venture over 84 billion worth of automobiles and automobile parts, against capital expenditures of less than 2 billion US dollars. The US automobile industry is a grown industry, engaging in vicious disputation in the highly dynamic car market. For instance, the industry spent a staggering $9,961,000 in advertising for the year 2007. From another perspective, the industry contributed even more to government coffers, spending $111,334,000 in taxes and license fees. T he study of the US automobile industry reveals some clear naval division according to size of the industries. The eight largest companies account for 91.3% of all encumbrances in an industry that has over 50 car-manufacturing companies. Of the top eight companies, the four biggest accounts for over half of the shipment revenue, scooping a significant 67.6%. The largest 20 companies take a 99.2% share of the export market, meaning that 12 companies following the top 8 companies account for just 7.9%. 30 of the automobile manufacturers in the US account for just 0.6% of the shipments to overseas markets. Under the Herfindahl-Hirschman index, the 50 biggest car-manufacturers have an index of 1,448.8 (US Census Bureau, 1). The index is used to establish how a group of firms fare with regard to size for the industry. According to the index, a measure out of below 1,500, as given in our case, usually indicates lack of concentration, with significant amounts of competition within the c orporations (Investopedia, 1). For the five-year period ranging from 2007 to 2002, the US car-market experienced considerable growth in revenues from shipments, with a small 3,386 million US dollars. over the same time period, the matter of shipments per employee fell from 1,295,000 to 1,094,000 (US Census Bureau, 1). In addition, the one-year average pay per employee fell from over 78 thousand USD to about 63 US dollars. From a geographical view of the US car market, it is apparent that most manufacturing interests are located on the eastern side of the US, off the noticeably off the coastal states. Also, the bend of establishments per million residents remained constant at 0.6. With regard to states, Michigan is the source of most shipments out of the US, with a 25.17% contribution to the shipment incomes. Only Illinois comes close with a 10.14% value of the shipments, while the others account for the remaining 64.69%. Michigan also boasts of 22 establishments for automobile m anufacturing. However, the leading state in this regard is California with 32 automobile manufacturing establishments. Noticeably, the industry has had considerable drops in the number of shipments, value of shipments, and annual payroll amounts. Shipments dropped by 7.6%, which closely matched the fall in establishments, which stood at 7.8% (US Census Bureau, 1). The drop in annual payroll was more steep at almost 20%. caller Analysis Honda Motor Company Background to Honda Motor Company Honda Motor Company is a multinational car manufacturing company incorporated in

Wednesday, June 19, 2019

The Effect of Culture in the International Collaboration Essay

The Effect of Culture in the International Collaboration - Essay ExampleAccording to the research findings, there are different types of collaborations apply by organizations around the world. The choice of the type of collaboration that organizations choose, as put by Shaughnessy, depends on the various factors such as the nature of the project they exigency to undertake, the objectives of the parties, the risks involved and the scale of operations. There are five main types of collaborations used by organizations in the modern world, informal agreements, strategic alliances, strategic partnerships, joint ventures as well as revenue and risk sharing partnerships. These are informal agreements characterized by the employment of little legal structures. They mostly involve verbal agreements amidst the boards of management of the two parties and usually, involve short-term agreements in projects that will last for a short period. Here, the number of risks faced by the members is rea sonably low and thus, the giving medication of the agreements base on mutual trust between the parties involved. However, in some conditions, very long lasting collaborations and joint business operations can melt in this manner. This type of collaboration involves organizations that lack any substantial degree of ownership and work jointly to gain mutual benefit in a strategically important relationship. Being mere relationships rather than specific inter-organizational structures, strategic alliances lack a well-defined legal form. The alliances align suitably, to the goals and objectives of the organizations involved. In strategic alliances, the partners stay on their autonomy but there is an existence of mutual dependency that aims at pooling their resources together and assist each other in dealing with the challenges posed by the market.

Tuesday, June 18, 2019

Case study for Coca Cola Marketing Analysis Example | Topics and Well Written Essays - 2000 words

For Coca sess Marketing Analysis - Case line of business ExampleCoca Cola is an example of such an establishment that has remained a proficient player in the beverage trade amidst the increasing competition in the industry. It was established in the nineteenth century and it is the market leader in producing, distributing and selling soft drinks in the international market. The company operates in nearly two hundred nations and has invented over four hundred brands since it was founded (The Coca Cola Company). Its leading brands include Coke, Sprite, and Stony among separates. Their success has its major rivals at bay including Pepsi and Nestle. This case study gives an in prudence analysis of the companys marketing strategy and the potential issues facing the company. COMPANYS OVERVIEW As far as the global manufacturing, distribution and change of soft drinks be concerned, the Coca Cola company in the lead. The company was founded in 1886 in Atlanta Georgia by John Pemberton who was a druggist by profession (The Coca Cola Company). His formula was later purchased by Asa Chandler in 1891 and this marked the advent of the companys business achievement. It sells approximately 400 brands making it the top company in terms of market capitalization. Additionally, the entity enjoys impressive customer loyalty and has licensed distributors in over 200 countries. This fact ensures that the entity is in a position to segment its customers hence the high profitably levels. In spite of the harsh economic conditions, the company has remained financially stable over the years. This is cod to the companys ability to adapt to cotemporary marketing strategies such as the use of online marketing through social media such as Twitter, MySpace and Face defend (The Coca Cola Company). The company has a history of having a strong corporate culture that propelled the companys success to date (The Coca Cola Company). For example, the company sponsored the FIFA 2010 World Cup and has constructed wildlife reserves. Potential Issues Facing the Company. Although the company has a huge part of the market share, it is clear that it faces stiff harsh competition from other key players in the industry. However, the company has been experiencing a constant increase in the stocks since 2008 as compared to its major rival Pepsi Co, Inc. Furthermore, the non alcoholic industry is increasingly competitive with many companies. There are competitive products in the market including carbonated drinks, energy drinks, packaged juices and fresh juices. Other significant competitors of the company include, Cadbury Schweppes plc, Nestle and Groupe Danone (Lopez 25). The competitive factors are with regard to pricing, product innovation, sales promotion, dispensing equipment, packaging, and production techniques. Moreover, the company competes in terms of brand name and trade mark protection. The company faces other issues in their operations that may have an impact on it s future. In the recent past there have been fluctuations in the value of the dollar against the common currencies. The larger theatrical role of the entitys income is generated outside the United States and owing to the strong performance of the dollar the firms revenues from other parts of the world its profits may crepuscle considerably (Lopez 38). The other issue facing Coca Cola is scarcity of water. The

Monday, June 17, 2019

Space Tourism Intro Essay Example | Topics and Well Written Essays - 1250 words

Space Tourism Intro - Essay ExampleOver-all Introduction of the issue This paper entitled Risk Management Analysis Space Tourism is about the identification of risks involvedand its ways to resolve and reduce themin acquire Space Tourism in full swing. It emphasizes the risk identification so that the concerned people can consequently apply them to reduce imminent risks in stead touristry, to save lives. This paperalbeit its delicate stand towards space tourismstresses the positive aspect of space tourism as an opportunity to bring recognition and luxury make a motion to new heights. It looks at space tourism not a profiteering racket by industry giants but as an evolving idea of space travel capable of giving a completely safe travel option for the next destination in the outer space. This paper has emphasized the aspects, which atomic number 18 to be scrutinized, in the area of space travel. Generally, these aspects are history of space travel, suborbital flights, past accid ents and, ultimately, the risk identification. The group behind this paper considers the topic as worthy of doing a detailed risk analysis since it is futuristic. And, it is simply bearing in mind the safety of people and of the entire space industry to stay their loss of lives and their investment, respectively. Lastly, we hope that this paper entitled Risk Management Analysis Space Tourism can be a good referenceand a scientific journal at thatfor concerned people. Unless(prenominal) we cant stress to NASAand other space administrations worldwidenot to take for granted the safety issues of human being spaceflights, the space industry cant assure the riding public of a superior and safe travel experience. History of Space Tourism When the Soviet Union successfully launched the Sputnik artificial satellite fifty-four years ago on October 4, 1957 (nasa.gov), the humanity was ushered in a new era of space science which dates back from the past. Later, on April of 1961, the newspaper The Huntsville Times of Alabama reported the feat of a Russian cosmonaut Yuri Gagarin in the banner Man Enters Space (nasa.gov). Gagarin is express to be successful in his April 12 orbital flight in the Vostok 1 spacecraft. Alan Shepard followed suit when he became the first American in space less than a month (nasa.gov). These, and few others, were monumental turning points in history which started to encourage people to raise the bar in luxury travel. Recently, space travel is becoming exclusive to astronauts or cosmonauts and multi-millionaires who can shell out millions of US dollars for a ticket, as well. notwithstanding, the more progressive breakthrough in space tourism is the relatively cheaper means to travel in the space. Private launch services and satellite builders are there to cater to people who wish to visit the transnational Space Station. (nasa.gov). For those who cannot afford, there is cheaper alternative. There is even an interactive video game for simulate d space tourism. For those who wish to have a taste inside the supranational Space Station, Vision Videogames LLC made an agreement with NASA to create the video game SpaceStationSim (nasa.gov) so that people can encounter lifelike missions inside the space station. But it has to provide actual experiences. To date, federal funds have also supported infrastructure development

Sunday, June 16, 2019

Geography and Climate Essay Example | Topics and Well Written Essays - 750 words

Geography and Climate - Essay ExampleColder areas also have lesser rainfall compared to warmer regions because warm air can hold more moisture than cold air (NASA 2). The climograph for Calgary shows a minimum rainfall in January of astir(predicate) 0.75 inches whereas the minimum rainfall recorded in Santa Fe is approximately 1.25 inches throughout the year. Latitude also causes places to have differences in their temperature ranges. Low latitude areas have little temperature ranges compared to high altitude areas. Temperature can range in Calgary from -22o F to 61o F, a range of 83o F, whereas Santa Fe has a smaller annual range, i.e. 72 o F, ranging from 14 o F in winters to 86 o F in summers.Continentality refers to the degree to which a place is affected by thermal variation and moisture. It gives parachute to a climate which shows large diurnal and annual temperatures (Oliver 303). Both Santa Fe and Calgary have a semi-arid continental climate. As a result, the climate is re latively rainless than that in coastal areas. The moisture content in the air is also lower, and therefore evaporation does not produce significant quantities of moisture as seen in coastal areas. This causes the amount of precipitation in Calgary and Santa Fe to be lesser than coastal areas. Also, another effect of continentality on weather is that areas experience very good temperature ranges. There is a grater range of minimum and maximum temperatures in both Calgary and Santa Fe both daily and through out the year as well. Winters in Calgary are more variable as compared to Santa Fe and whereas the summers are short. Average temperature can fall as low as 14 o F in January and can be as high as 61.5 o F in July (CalgaryIintl, Alta., Canada). On the other hand, average daily temperature in January in Santa Fe is 40.0 F and in July, its 91.0 F, showing lesser variations than Calgary. Annual precipitation in Calgary is 16.23 inch, whereas that in Santa Fe is 14 inches.Elevation r efers to the

Saturday, June 15, 2019

Exploitation in the Social Structure of Civilizations Assignment

Exploitation in the Social Structure of Civilizations - Assignment Example discussion Let us first take the recordings of Diego Duran regarding the Aztec civilization, its social structures and beliefs. Though these recordings were made from interviews taken from voyagers or their descendants at least fifty years aft(prenominal) the Spaniards had encountered the Aztec empire, yet we find a compelling story that shows the interest that Duran must have had in recording them for posterity. They do not aspire to compare ace civilization to another in terms of superiority or greatness rather they are a faithful representation of the Aztec civilization as seen by means of Spanish eyes. Quite likely the Spaniards were taken aback at the elaborate social structure that existed in the Americas so far away from home, even though they felt revulsion at the human sacrifices that were made to the sun god Quetzalcoatl and other demigods. Contrarily speaking, the Spanish treatment of the Aztecs at the hands of Hernando Cortes was no slight barbaric and demeaning, and leaves one with a bitter taste in the mouth. As Mel Gibson has so eloquently shown in Apocalypto, neither could aspire to be on the high moral ground. What is clear is that religion and economics had a key role in separating companionship into classes. The upper class consisting of the king and nobles led an existence sort of different from that of the lower social classes. There were three ways in which a man could aspire to move upwards in society, through distinguishing himself in battle, through entering the priesthood or through being a good trader and marketer (Stryker, 604). Quite consciously, hundreds of families would have aspired to rise in the annals of society but only a few would have achieved this feat. Imagine a normal Aztec not even being able to wear sandals on his feet, date this was a privilege given only to the nobles and leaders in society. The average Aztec would have led a life of s ubsistence and want. Indeed, circumstances could become so dreaded that a man could sell his wife and vice versa in times of economic distress. Or they could decide to sell the child that troubled them the most, claiming that he or she was a misfit and a troublemaker. The Aztecs treated their prisoners of war in brutal fashion, seeking no doubt upward social mobility by sacrificing their victims to the gods and after having torn their hearts out, would even take home the carcasses to feast upon like cannibals (Stryker, 603). Moving on to the account given by office Kangxi of the Qing Dynasty, he regards the supreme power of the King was to be able to pardon or condemn a subject, thereby ending his life or sparing it. It was of course necessary to make an deterrent example of dishonest men like Hu Chien-Ching, a corrupt official who terrorized his neighborhood and usurped their lands, for which the King recommended he be executed along with his family in his native place. At other times he made a careful review of appeals and spared people their lives. The King appears to be a practical man, and is disdainful of the practices that men workout to gain favor with him. Quite often these men talk of principles and teaching that they themselves do not follow, but seek to impress by their noesis. This kind of knowledge is empty and useless, much in the manner of

Friday, June 14, 2019

The different directions in Judaism Essay Example | Topics and Well Written Essays - 1000 words

The different directions in Judaism - Essay ExampleMost people translate the Halakha as a Jewish law, however, in the real sense, it means the path. That is the manner in which people ought to live. On this basis, most Jews who lived in the diaspora used the Halakha as a quotation of their religious and civil laws.In the contemporary and modern Jewish society, the personal and the family laws ar always under the authority of the rabbi courts. On this basis, the family and personal values be always under the steering of the Halakha. In interpreting the Halakha, there are three main Jewish directions, namely the Orthodox, the liberal, and the Hasidism directions. The Orthodox Jews believe in the Halakha as a religious system (Landesmann and Jones, 2012). They believe that the Halakha is a revelation of the will of God. Orthodox Jews believe that the Rabbis have a duty of interpreting the written Torah, where its aliment are not clear. However, they must only to do so with the regu lations specified by Moses, at the mountain of Sinai. These regulations under consideration were transmitted orally, and they are distinctly explained in the book of Talmud.Orthodox Jews believe that no rabbi has an authority to change the Jewish laws contained in the Talmud and the Torah, all they can do is to give an interpretation of these laws. However, their interpretations are subject to change, and reconsideration. According to the Orthodox Judaism, the role of a woman is dynamic and complex. Women under the Orthodox Judaism are allowed to engage in business, to observe the Sabbath, to engage in activities aimed for their personal development, and this includes academics, etc. The role of Jewish Orthodox women revolve around the mentioned areas. However, the Halakha does not identify the specific duties and roles of women amongst the Orthodox Jews however, the orthodox Jews believe that the Halakha only provides guidance on how women should live. The orthodox Jews believe in the role of a

Thursday, June 13, 2019

Research wk2 Essay Example | Topics and Well Written Essays - 500 words

Research wk2 - Essay ExampleThere will be several ethical dilemmas match to the APA Ethical Principles of Psychologists and Code of Conduct (2010) that I will face. Standard 3.04 is the first of these ethical concerns that I will face which encompasses a clause for avoiding harm. In wondering(a) these juveniles to gain an understanding of their motivations and the reasons behind their criminal activities there is a high probability of exposing them reliving traumatic incidents and disturbing personal experiences. Standard 4.02 that pertains to limiting confidentiality is another(prenominal) obstacle on the research that I would be undertaking. This ethical consideration would limit the amount of in cookation disclosed by the subjects regarding their offenses and confidential details of the detestation scene. This information could be critical in aiding the research however due to the confidentiality ethical dilemma further complexities in terms of reaching a universal conclusion can be deterred. Furthermore according to Creswell (2009) there might be a rising need to gain a consent form from the participants which might pose to be a problem since these juveniles might be hesitant to officially sign documents that pertain to formal information collecting.

Wednesday, June 12, 2019

OUTLINE ASSIGNMENT Research Paper Example | Topics and Well Written Essays - 500 words

OUTLINE ASSIGNMENT - Research Paper ExampleMyrrh possesses effective antimicrobial activity, which is why it has been used in the treatment of many diseases. The other substance used in natural wound meliorate is the propolis, which is collected by bees Apis mellifera from trees. It has antimicrobial, antiulcer, anti-oxidative and antitumor. tralatitious wound care has shown excellent results since they support the scientific that a most environment helps the healing process.II. Natural wound care methods entail the stimulating of the proboscis to produce hormones and cells to help in the healing process. Hyperbaric oxygen therapy is an example of a natural wound care method. It involves the inhalation of pure oxygen at common chord times the normal pressure. Blood carries the pure oxygen all over the body. It helps in fighting bacteria and stimulating angiogenesis. It promotes the release of stem cells and growth factors. ground substance therapy with OTR4120 also helps stimula tes growth factors to speed up the process of healing. The OTR4120 helps in restoring the natural cell microenvironment, which aids in preventing an impaired wound healing process (Tong, et al., 2012). It helps the healing process by support an intrinsic regeneration of tissues. It corrects the factors that disturb the wound healing process.III. The healing of wounds in diabetes is done using many methods. The process abide use traditional wound care practices that use honey, propolis, myrrh and other products with medicinal properties. Honey and propolis helps in speeding up the healing process for diabetes patients (Loft, Badra, W., & Alenzi, 2015). However, excess clinical evidence is required to determine the effectiveness of honey in clinical settings. In the use of honey, the MPH paste was applied to aid in the treatment of deep wounds. The natural methods of the healing of diabetes wounds are hyperbaric oxygen therapy and matrix therapy with OTR4120. According to research, b oth methods

Tuesday, June 11, 2019

Texas History. How to Get Rid of Slavery Essay Example | Topics and Well Written Essays - 6500 words

Texas History. How to Get Rid of Slavery - Essay ExampleTexas Secession ConventionIn the month of January and February of the year 1861, a meeting was stages in Austin and voted to succeed from the trades union.The call to drug withdrawal actually began from October 1860, when it became apparent that Abraham Lincoln would be given the charge of presidency.The secession of South Carolina and five other states exacerbated the maculation even further and added on to the intensified pressure that already existed for the implementation of secession policy.In Texas, only the governor could summon the legislation to hold a special session, but Governor Sam Houston refused to do so in the light that the secession hype would cool down. This compelled, Oran M. Roberts, the chief justice of Texas Supreme Court, lavatory S. Ford and other imminent leader to take the situation into their own hands.They made a call for elections on January 8, 1861 in the press of delegates to a secession conve ntion, which was duly granted by the legislature.On January 28, 1861, the delegates to the convention elected O. M. Roberts as the presiding offer and on 29th January, John H. Wharton moved that without determining now the look in which this result should be effected, it is the deliberate sense of this Convention that the state of Texas should separately secede.The convention delegates called for a proper referendum to solve the secession issue.On February 1 the House with the governor sat to give its final vote, which resulted in 166 votes in favor of secession and 8 against it. The Texans ratified the Secession on February 23rd repayable to the Conventions Public Safety Committees move to authorize the seizure of federal property in Texas. In March, the Convention nonionised various meetings, which resulted in taking Texas out of the Union and allied it with the confederacy. Battle of Sabine Pass The battle took place on September 8, 1863, which was an attempt by the Union to i nvade and occupy regions of Texas during the Civil War. The motivation behind the attack was the need of cotton by northern textile mills and concern nearly French interference in the Mexican Civil War. In September 1863, the Gen. Nathaniel P. Banks was sent with 4000 soldiers under the command of Gen. William B. Franklin to capture Sabine Pass, where the Sabine River flows to the Gulf of Mexico. The westerly Gulf Blockading Squadron of the United States Navy sent forces to protect the piece of land. The Union lost their opportunity to launch a surprise attack when a blockader missed its scheduled meeting with the ships from New Orleans. However, a plan took shape and the Navy Commander scheduled the gunboats to enter the fort through the passes so that the parade could pass without being noticed. Meanwhile the Confederates remained in hiding and gathered reinforcement near the fort Odlum. The Union armed ships began their advancement into the fort, continually firing in the proc ess. The Confederates cannoneers also geared up for the attack when the Union ships came under the 1200 yards radius. The Confederate artillery man shot the cannon with such precision that it destroyed the Union warships Sachem, made Arizona run for its life, grounded Clifton which resulted in ground combat between the two contenders and compelling another ship Granite City to flee the battleground. This led to the finis of the war and the Confederate captured 300 Union pri give-and-takeers and two gunboats. The artillery skills had won the battle for the Confederates Andrew Jackson Hamilton He was born in Huntsville, Alabama on January 28, 1815 and was the son of James and Jane (Bayless) Hamilton. He had the privilege to become the governor of Texas he was educated and admitted to the bar in Alabama. For three years, he practiced law in La Grange, Fayette Country He tied the marital knot with Mary Bowen and had two sons and four daughters form her. His political career began in 18 49, when Gov. Peter Hall. Bell plant him as his acting attorney general. In 1859 won

Monday, June 10, 2019

Marketing Audit Report for MAC COSMETICS Essay Example | Topics and Well Written Essays - 3000 words

Marketing Audit Report for MAC COSMETICS - Essay ExampleThe essay Marketing Audit Report for MAC COSMETICS discusses the marketing report for mack Cosmetics to analyze the various operational aspects that are involved in ensuring the company repugns. Marketing can be defined as the achievement of corporate goals with ensuring the operations meet and exceed customers needs better than the competition. Marketing for different products provided by different companies within the same industry is conducted with the aim of beating the competitors by the market share and achieving high profits for the organization. The development of a strategic marketing plan is essential in ensuring that the products of the company are able to compete effectively in the market. Competitive markets require organizations operating within the industry to adopt intensive marketing strategies to ensure that they compete effectively within the market.The agency arguing of an organization can be defined as a brief statement that defines the purpose of establishing the business while identifying the reasons behind the existence of the company. The military commission statement for the company seeks to provide products which fit individuals of different demographic states. Within the mission statement of the company, it states clearly the goals which the company seeks to achieve and the responsibilities of the company to the customers. The mission statement is important to the company because it establishes the direction of the company in terms of defining the goals and targets.

Sunday, June 9, 2019

An investigatin into the brand identity of fashion concessions in UK Essay

An investigatin into the brand identity of fashion concessions in UK department store - Essay ExampleThis research, using primary and secondary data analysis shall determination extensive research on fashion, retailing, host and concessionaire relations, branding design, and factors that inter-relate in all these aspects. The data to be gathered shall try to answer brand recognition of fashion concessions in UK department store. Other related data shall also be presented.This study shall unravel the making of an association of quality service and products in a prestigious London department store with the stores design aspects, consumer behaviour as well as the concessionaire and host relationship built.Branded products atomic number 18 in essential. The brand-consciousness of consumers is continually growing inside the fashion industry. (Gretz, 2000) Many fashion brands have been considering setting up department store concessions to fulfill the brand demand of their customers.Co ncessions are a way of allowing a retailer to extend the product range offered within the outlet without experiencing some of the risks associated with buying merchandise. The basis of a concession, which may be referred to as a shop-in-shop, is that a retailer allows a supplier of a particular brand of merchandise a designated amount of space within an outlet from which those goods are sold. (Varley, 2001, p112)With this study, researcher was able to gain in-depth knowledge on the relations between fashion branding and host-concessionaire as may be both(prenominal) perceived in visual store and product design or display. Among other things, the research also found out these attributes are not astonishingly absent in the chosen department store or retail outlet for this study. In fact, the department store have presented more than what is necessary or has been studied about the subject matter, or that, it exceeded expectation to a certain degree, it being a premier and prestigiou s

Saturday, June 8, 2019

Philippines Essay Example for Free

Philippines EssayI. Expected Argument The academic progress of the students will increase because side is the medium used in supranational textbooks and schools.II. Rebuttal The students academic progress may be hindered due to unfamiliarity with the language, especially more so with the less fortunate people in the country.III. definition For m either in the Philippines, the fluent use of the side of meat language has always indicated a level of superiority or better upbringing among its people. This and the fact that the slope language is most commonly used in an international basis has lead people to believe that English is more valuable than the Filipino or any other indigenous language. This idea, I believe, is false. The English language is not a gauge of ones intelligence, as subjects such as science and Math do not need to revolve around the language. Recent studies have shown that students who study in their own native tongue have obtained the highest scores, for typeface students from Japan and Korea. Eduardo Gullas, an old lawmaker from Cebu, says that Filipino children failed in the recent math and science tests given by DepEd because they have poor English. He also added To sustain with, math and science manuals and most other books for that matter are in English, so learning becomes extremely difficult if the student has deficient English.Also, using English puts poorer student at a disadvantage. Not everyone speaks English at home so children from Tagalog speaking home are less likely to understand the lessons. Also, the students would also be more concerned whether their use of English was correct and be more hesitant to recite and speak in class, thus hindering their educational development.IV. Examples1. Malaysia said it will drop English as the language of instruction for math and science in schools, in a highly sensitive close that has split opinion in the multiethnic country. The government cited a 2008 survey which found tha t students performance in math and science had fallen since it had been taught in English, and that verdant children were hit particularly hard.2. An article by Saffir Rammah states that We (Academy of the Punjab in North America) believe that the native language is the only genuine and true medium of expression for any nationality, in particular for communicating their emotions and feelings to each other. Millions of Punjabi sons and daughters who even today write letters to their Punjabi speaking parents, friends and other loved ones in Urdu or English are missing the most basic and vital mode of communications available to human beings their own mother tongue.If we sit down for a few moments and ponder on this phenomena, we will soon come to the conclusion that it is a crime against a whole nation to deprive them the proper training in compose expression in their own language and that, that the use of Urdu as the medium of instructions in schools is the main cause of low lite racy rate in western Punjab and is one of the main impediments of economic growth and development of civil society. We take note of the fact that all developed nations, including the Asian Tigers that have recently do major strides in economic development, use their native languages as medium of instructions in schools. We are convinced that education in Punjabi is a mustiness for the educational, economic and civil development of West Punjab.3. In a study done in 2006, 52% of Filipino students prefer bilingual classes with both English and Filipino rather than pure and straight English in subjects like Math and Science because its too hard to understand and because some lecture have no direct Filipino-English meanings.

Friday, June 7, 2019

Skeletal and Muscular System Relationship Essay Example for Free

Skeletal and hempen System Relationship EssayPinak Patel Anatomy and Physiology Professor Jargen December 14, 2011 Skeletal System and Muscular System In anatomy and physiology we study the structure of living things and the function of living clays. In physiology, the scientific method is applied to determine how contrastive electric organisms, organ system of ruless, organs, cells, and biomolecules carry out the chemical or physical function that they pay back in the living system. Both anatomy and physiology atomic number 18 subcategories of biology. Throughout our class we have discussed many different systems of the body. One system that is very grievous to the human body is the muscular system, which consists of three different types of muscularity tissue. Along with the muscular system is the gaunt system, which consists of the b one and only(a)s and the different types of tissue it contains. Both of these systems have many different functions, and can be interc onnected together. These two systems work together and they cultivate the musculoskeletal system. The muscular system consists of three different types of muscle tissue and it has four different functions. The muscular system as well as encompasses many properties.The three different types of muscle tissues it includes atomic number 18 skeletal muscle, cardiac muscle, and smooth muscle. The skeletal muscles main function is to move the bones of the skeleton. This muscle is voluntary and is also striated, meaning that it is striped, which is due to the muscle fibers that are combined into parallel fibers. Some of these muscles can be controlled unknowningly. For example, the diaphragm of the human body continues to alternately contract and unwind while we are asleep, allowing our lungs to expand to breathe. The cardiac muscle tissue is found only in the heart.It is similar to the skeletal muscle in that it is striated, but it is also different in that it is involuntary. The smoo th muscle tissue can be found within the walls of the digestive tract, blood vessels, and airways of the respiratory system. This tissue is nonstriated, which means that it is non striped and the fibers are not arranged into parallel orderly bands like the skeletal and cardiac muscle. The smooth muscle tissue is also involuntary. The muscular system has four key functions. It produces body movements, and stabilizes the body positions, for example, it holds contraction of the neck uscles that hold ones head upright. Another function of the muscle tissue is that it is the storange and transferee of substances within the body skeletal muscle contractions move lymph throughout the body, and help return blood to the heart. The final function of the muscle tissue is that it helps to maintain ones presence. Each skeletal tissue is made of hundreds of thousands of cells called muscle fibers. The fascia is a component of connective tissue and it is a broad sheet of fibrous connective tiss ue that surrounds and supports muscles and other organs.The external part is the deep fascia that consists of theee layers of connective tissue. The epimysium is the outermost later that encircles the entire muscle. The perimysium surrounds groups of ten to hundereds or more man-to-man muscle fibers, seperating those into bundles called fasicles. Then in that respect is the endomysium, which seperates each individual muscle fiber. The nerve and blood supply of the muscle tissue consists of arteries, veins, and nerves that run together. There are somatic motor neurons that stimulate the muscles to contract.These neurons begin in the brain or spinal cord and extend by an axon to a group of skeletal muscle fibers. All in all, the skeletal muscle tissue contains many vital things, in order for everything to work properly. The skeletal system has many functions as well, just like the muscular system. The skeletal system has six different functions support, protection, assistance in mov ement, mineral homeostasis, blood cell production, and triglyceride storage. Unlike the muscular system, posture is not a function of the skeletal system.There are also four types of cells that are present in bone tissue. The first type of cells is the osteogenic cells, which are unspecialized stem cells that are the only bone cells that divide. Another type of cells is the osteoblasts, which are the bone building cells known as the immature bone cells. Then, there are the osteocytes, which are the mature bone cells and are the main cells in the bone. They exchange nutrients and wastes with the blood, which help maintain the bones normal metabolism.Finally, the osteoclasts, which are the cells that consume powerful lysosomal enzymes and acids that break down the matrix (resorption). The bone tissue also has nerve and blood supply that also consists of arteries and veins. Although one can claim that there cant be much inter-relation with the skeletal and muscular system, there are some relations to be made. First of all, vertebrates move by the actions of muscles on bones. Therefore, tendons attach many skeletal muscles across joints, allowing muscle contration to move the bones across the joint.Muscles generally work in pairs to produce movement when one muscle flexes or contracts, the other relaxes. Next, the skeleton and muscles function together as the musculoskeletal system. This system is often treated as two separate systems, the muscular, and skeletal plays an grand homeostatic role allowing humans to move to more favorable conditions. Certain cells in the bones produce immune cells as well as important cellular components of the blood. Therefore, bone also helps to regulate blood calcium levels, serving as a calcium sink.Finally, the rapid muscular contraction is important in generating internal heat, which is another important function that can relate to bone tissue as well. There are many important systems that we study in anatomy and physiology. The skeletal system and muscular system are just two of them. Both of these systems have many functions that can be studied in depth. Although there are quite a few systems that arent very comparable, these two systems make an exception. In conclusion, both of these systems, bones and muscles, work together in many ways and can be inter-related to a certain degree.

Thursday, June 6, 2019

Macbeth Relationship Analysis Essay Example for Free

Macbeth Relationship Analysis EssayI found the relationship between Macbeth and lady Macbeth very interesting in the play. In Act I they are completely devoted to each other. Love, respect and charge are the contents of their relationship. The trust in the relationship is revealed right at the beginning when Macbeth sends his wife a letter telling her about the witches and the predictions This have I thought good to comport to thee, my lovemaking partner of greatness, that thee mightst not lose the dues of rejoicing by being ignorant of what greatness is promised thee. (I, v, 10-13).The affection between the two is clearly shown when Macbeth salutes his wife with My dearest love (I, v, 58) and also on the letter where he says my dearest partner of greatness (I, v, 11). The respect comes when Macbeth listens to his wife, which talks about the murder. He respects her opinion and gives her a polite answer We will speak further. (I, v, 71).In Act I, ii we see that King Duncan co nsiders Macbeth a brave soldier and good man O valiant cousin, worthy gentleman (King Duncan, I, ii, 24). This can be considered a weakness or, perhaps, strength in the relationship, it depends on the point of view. It is a weakness if we analyze Macbeths side. He is too full o the milk of human kindness that wouldst thou holily wouldst not play false (I, v, 16 21).It is strength if we analyze bird Macbeths side. She has a very strong nature and knows Macbeths weak points, therefore manipulating and controlling the relationship. She uses of a great argument in Act I, vii accusing Macbeth for not having the courage to do what he wants Wouldst thou have that which steem st the ornament of life, and live a coward in thine own steem, letting I hold not wait upon

Wednesday, June 5, 2019

Cystic Fibrosis: Molecular Mechanisms and Diagnosis

Cystic Fibrosis Molecular Mechanisms and DiagnosisCystic fibrosis is a membrane head disorder which is commonly affected in the autosomal recessive disease of white populations. It is overly identify at birth by a certain condition cal direct meconium in dischargeinal obstruction which means intestinal obstruction. In the advance stages, clinically it has been diagnosed by adhesive viscous secretion of the pancreas and lungs (Gelehrter, 1998). Many classs of direct research has failed to recognise the proper(postnominal) agent which is involved in cystic fibrosis (cf., although there atomic number 18 rough various indirect research done which has indicated that there appe bed an abnormality in the transport of ions during the process of cubicle membrane develop workforcet. A very familiar diagnosis has been use to recognise this disease which is eminent increase of chloride content in hidrosis. Children deplorable from this disorder develop pancreatic insufficiency which is usually treated with enzyme supplementation, antibiotics and physical treatments which atomic number 18 apply to reduce the chest infection. Earlier the survival average is close to 25 years. (Gelehrter, 1990). But in a recent knowledge, it has been said that the life expectancy for cystic fibrosis patients has increased over the last 40 years. It has been necessary to localize the respiratory viruses in Cf to make the clinical decision to proceed with the necessary treatment. (cited in Wat, 2008). It is said that one can calcu advanced approximately the frequence of heterozygous carriers would be ab knocked turn up(p) 1 in 25 individuals. There are various research works done on cultured cells and wight models to further study on the basic defects of the disease and find a successive treatment. (Hodson, M.E., 1995).HISTORYFrom centuries the study and research of Cystic fibrosis has been done. Earlier people started diagnose this condition in the newborns collec table to the salty taste in their skin. The survival rate was so low as six months. But as years followed, during the 1930s, a scientist named Guido fanconi had described the symstoms as gastrointestinal symdrone only latter named it as cystic fibrosis. The research had advanced when the cystic fibrosis gene was discovered following the study of mendels law researched by Gregor Mendel. The genetic knowledge on this finicky disease was made more improving which indirectly improved the survival ascepts of CF patients. By 1980s, a deeper understanding of human genetics were developed. In 1989, two researchers had isolated the damaged gene in causing CF which was the main cause in affecting the chloride channel function. These were the channels which were cooperateing in the movement of pissing and salt in the cell walls. Further study on this is making it thinkable to understand and find a treatment for this genetic disease.In recent years, various study via Gene theraphy has been helping various researches to fix the damaged gene. If this particular gene is fixed, the possible pr even sotion, treatment and cure of CF would become a (Giddings,2009)Basic molecular genetics of CfIn the year 1985, several groups were experimenting on gene therapy by linkage analysis, a linkage was observed on the chromo or so 7, which in turn proceeded with testing some of the markers on chromosome 7 where they order CF gene near to these markers (met and J3.11). Techniques like physical mapping showed that the distance between these markers was approximately 1.6 million bp, which is as large for approximately 50 genes. Various enkindle research were made in which it was put in that a vast majority of chromosomes carrying the Cystic fibrosis mutation were also carrying a particular allelomorphs for XV-2c and KM-19 which was further named as allele for XV-2c and + allele for KM-19. This type of hapotype (-/+) showed approximately in 25% of normal chromosomes, whereas res t showed other different patterns. A term was defined for this type of disease gene associated with a allele with the nearby markers, which was named as Linkage Disequilibrim. This term was made used to understand that these CF mutated genes were being descended from a common ancester. (Gelehrter, 1998)In a recent research, a genetic analysis was conducted by carefully cloning of a 500,000 bp candidate which progenyed in three possible genes from the limited region which was studied. In testing under northern blotting technique it was found that this specific gene was coding for a 1480- amino acid protein including 26 exons with a length of 250,000 bp of desoxyribonucleic acid and the mRNA transcript was found to be 6129 bp long.In further studying a cloned and sequenced cdesoxyribonucleic acid was prepared using the sweat glands of a Cf patient, it was found that there was a difference in exon 10 from a normal sequenced gene. There was a deletion in the 3 -bp found which energy select caused the deletion of a single amino acid (phenylalanine) at the specificresidue 508. (Gelehrter, 1990). This type of mutation is known as Delta F508 or F508. Patients with homologous delta F508 mutation depart tend to suffer with severe symptons of this disease, causing a very heavy loss of chloride ion transport.This causes an improper balance in the sodium and chloride ion ratio, eventually secreting a thin, mucous secretion secretion in the lung area which traps bacteria, this causes severe lung infection, resulting a high mortality rate in CF patients.CFTR geneThis gene was initially cloned in 1989 in which it was mapped to human chromosome 7q21, with more interest in this particular region, researches were able to indentify 2 more closely linked markers other than (labelled MET and D758) which were D75122 and D75340, those were 10 kb part. Using lambda genomic deoxyribonucleic acid libraries, 280 kb of DNA were sequenced which were used to make long range restrict ion maps. These were also probed with cDNA clones to isolate a total of 500 kb. This can be seen in the figureBy using various approaches like binding zoo blots, northern blots and cDNA libraries the genomic DNA clone was isolated. Four different regions were isolated, let out of that, only one proved to be CF gene which was 6.5 kb sequence in length. Eventually, it was concluded that the CF gene controls the CFTR (cystic fibrosis transmembrane regulator) which encodes chloride channels which were responsible for the water transport on the plasma membrane of the epithelial cells which were connected to the lung air slipway. This mutation was causing the problem.Structure of the CFTR geneAfter sequencing the CFTR gene, further study was done on it. The sequenced coding region of this gene showed a polypeptide molecular mass of 168138 daltons. The best site seen in this predicted protein was that it showed two repeated motifs, which showed some similarities to the nucleotide-binding airfields (NBD) which is present in the membrane bounded protein. These membrane consisted in them six hydrophobic regions which composed 234 amino acids.Hydrophilic domainsThese 2 hydrophilic domains contains approximately 150 amino acids in which some phenylalanine residue has been deleted at the region of the first NBD which shares similar homologies with the proteins which binds with the nucleotide. These two motifs are connected by a highly charged cytoplasmic domains referred as R- domain or regulatory domains. This domains encodes 13 exons that help in the phosphorylationby protein kinase K and rest helps in binding sites by protein kinase C.These domains and nucleotide binding folds in the binding sites purport that hydrolysis is involved in the transportation of CFTR gene.CFTR PromoterIt was found out that CFTR gene had a addition promoter region with a size of 3.5 kb, later on, it led that these promoters showed the characteristics of housekeeping gene along with tissue specific functions. There were five reasons that were focused to show that the CFTR gene had these charactertics which were as followsThere were no TATA box ingredient within the first 500 basepairs of the transcription sites.The GC content in the promoter region was high.There were addition multiple minor transcription sites identified along with the major transcription sites.Couple of SP1 sites were also identified.There was a very low expression of the CFTR gene found in the epithelium layer. some other conclusion was made that the CFTR gene might control transcription regulation.(prin mg, tho)Phenotypic function of the diseased gene To understand the phenotype of the disease, it has been patronizeed that an individual suffering essential have two copies of a mutated Cystic fibrosis transmembrane conductance regulator (CFTR) gene to be expressed. It has also been understood that the festering of this disease in different individuals varies due to derivative instrument influ ence by environmental and genetic factors. This various different forms of other genes can affect the phenotypes of the mutated gene of this disease.MUTATED GENEAs it been understood that the most common mutated gene found in most cystic fibrosis defective gene is the delta F508. A detailed study about this gene was done in which it was found that CFTR protein helps in encoding single amino acid at position 508 on the chromosome 7. As this mutation affects the CFTR to perform its work in the cell and prevents it from fixing itself in the cell membrane. Usually it is seen that, a newly synthesized CFTR protein adds itself to the missing chemical group by folding itself into appropriate shape which are escorted by their specific molecular chaperons to the surface of the cell. Because of the presence of this mutated CFTR gene, the imperfect CFTR binds onto the cell membrane which has a defect while opening and closing during regulating the chloride ion flow within the cell membrane.Th ere are different mutated genes, in which some do not this synthesis or any modification or integratation into the membrane of the cell. Sometimes, these mutated genes fail to even respond to the signals within the cell that are responsible for the opening and closing of chloride flow. In some cases, the CFTR protein enters the cell membrane and also responds to the cell membrane but there would show a problem when the channel opens and there is improper flow of chloride ion out of the cell. Different mutations vary with different patients, patients with absent or very low CFTR protein in its cell membrane would cause severe disease causing depleting pancreatic functions. There are patients which have delta F508 mutation on twain CFTR gene copies, this causes very poor pancreatic function which would secret high amount of mucus causing varying degrees of infection in the lungs. Another CFTR mutation namely R117H also develops a partial functioning CFTR protein, this mutation pairs with the severe mutated gene delta F508 causing the CF disease severe but varying in lung disease. It has been seen that some men who have been detected with this particular mutated gene R117H shows only one symptom of CF that is being Infertile which is due to lack of vas deferens.Inheritence of the CF geneDiagnosing cystic fibrosisIn most cases, cystic fibrosis is diagnosed by screening tests, which are carried out very early in life. However, some babies, children and even young adults have some unexplained illness in future so they are diagnosed later. There are four main ways of diagnosing cystic fibrosisnewborn testingantenatal testingcarrier testingsweat testingNewborn ScreeningIn newborn screening there are two tests the first one is blood test in which small amount of blood is contactn from the babys heel and ravishred onto the card and it is examined in the laboratory for CF and it is also test inherited conditions, such as sickle cell anaemia and phenylketonuria.. Anoth er test is genetic test in which saliva sample taken from the cheek and check whether a newborn has faulty CFTR genes.Antenatal testingThis test is done during the womens pregnancy to know that fatus has CF or not. There are followingAmniocentesis in it go intos a needle by means of abdominal wall into the uterus and take amniotic fluid surrounds the baby and tested in the laboratoryChorionic villus sampling In it needle passed through the stomach into the womb sometimes a fine electron tube passed through the vagina into the neck of the uterus as an alternative. And take chorionic tissue which is a tiny piece of the developing placenta and these chromosomes which are in the cells of the tissue are examined in the laboratory for CFTR genes are normal or not.Both tests have risk of complication and also chance for miscarriage so it is offered only those mothers who have high risk of having child with the CF.Carrier testingPeople who have two CFTR genes one is normal and another i s faulty are CF carriers. So carriers pass faulty CFTR genes on to their children. This is simple test which is uses mouthwash to make sure that person is a carrier of cystic fibrosis. Swishing the mouthwash to see the cells. And these containing cells are checked for the faulty gene.Sweat testIf blood and genetic tests have positive sign for CF so for confirmation sweat test diagnosis using This test measure the amount of salt in sweat. For that in one treatment room small area of skin on an arm or leg tested. Rub this skin with sweat producing chemical and then produce gentle electrical current with help of electrode it gives warm timbre .collect sweat on a pad or paper for analze. High takes of salt confirm diagnosis of CF. (180,205)Immunoreactive TrypsinognThis analysis is used after sweat test if little sweat measured in newborns. Blood samples are taken after 2-3 days of birth and examined for immunoreactive trypsinogen (IRT) which is the increased levels of pancreatic enzy me. If IRT level is high then also it is not strong indicator of CF. Because infants with intestinal malformations and condition as bowel obstruction also have high level of enzyme which is for function of impair pancreatic.Lung roentgen rays and function testsIn the tests measure the amount of air the lungs can hold and how fast a person can breathe out to show how lungs add group O and remove carbon dioxide from the blood with the help of chest X-ray which show lung scarring from recurrent inflammation.This test do not confirm a diagnosis of CF but help in evaluating the severity of an individuals lung damage.Sinus X-rayThis test give signs of sinusitis, which indicates an infection and inflammation of nasal cavities. The X-ray shows the underlying cause becomes important for sinusitis. By cause of sinusitis is showing allergies and poorly functioning immune system.DNA mutation analysisFor highly specific result we used this technique for CF to look for the presence of many muta tions in the CFTR gene. In it DNA isolated and purified from the blood sample or from a obnubilate inside the cheek and for detect disease genes and indentify mutation within a specific DNA sequenced used micro array technologySputum culturesFor this test, take a sample of your sputum (spit) to see what bacteria are growing in it. If there are bacteria called mucoid Pseudomonas, then it is advanced CF that needs aggressive treatment. (Giddings, 2009)TREATMENTIn early years, there were no proper complete cure for cystic fibrosis . This has changed in recent years due to various researches done to treat CF which have been improved drastically. The aim for the treatment of cystic fibrosis are to Prevent infection in lungs,Remove the thick and sticky mucus from lungs, Prevent obstructers in intestines and to Provide adequate nutrition.(http//www.nhlbi.nihHYPERLINK http//www.nhlbi.nih.gov/.gov/)Treatment for lung problemsIt is essential to begin the treatment by reducing the infection and removing the thick and sticky mucus from the lungs. This can be done by performing the following lung treatment methods.CHEST PHYSICAL THERAPHY (CPT)This theraphy is also called percussion. CPT include pounding the chest and back over and over with the hands and a device that reduce the mucus layer from the lungs. Breathing techniques are also helpful to remove mucus from lungs. This techniques involve forcing out of some short or deeper breaths and following with a relaxed breath. The major purpose of this therapy for CF is to increase clearance of mucus and control infection in the lung and also to provide adequate nutrition and prevent intestinal blockage.MEDICINESThis is the primary treatment for the cystic fibrosis. Using medicines it helps in treating lung infection, decreases the swelling ,reduces the mucus and also opens the airways. The following types are the antibiotics used for cystic fibrosis treatmentOral antibiotics are use to treat the lung infection.Inhaled anti biotics are used to control the infection caused by the pseudomonas bacteria.Intravenous medicines are used for control the severe infection.Anti-inflammatory medicines used to reduce swelling in airways.Drugs or steroids such as azithromycin, ibuprofen, prednisone and pentoxifylline are used to reduce inflammation.For the treatment of bacterial infection various lung antibiotics such as nebcin, tobrex, ciprofloxin, myambutol, biaxin, azactam are usedExercise Aerobic exercise can help to reduce and clear the mucus from the airways. Regular exercise also enables to cut back on the CPT.Intracytoplasmic sperm injection is used to provide fertility for men with cystic fibrosisLUNG TRANSPLANTATIONLung transplantion is a effective therapeutic option for the cystic-fibrosis patient. The successfully lung transplanted patients are able to control diabetic problems easily as the patients exercise capacity improves and the respiratory infection reduces.(Madden, 1992).In lung transplant ,the infected lung is replaced with a healthy lung by surgery. If CF is very advanced then lung transplantion is a good option. It is a major operation and sometimes also leads to some serious complicationsOxygen TherapyIf oxygen level is very low in the blood then oxygen therapy is very effective(http//cystic-fibrosis.emedtv.com).NUTRITIONAL TREATMENTC.F causes many digestive problems such as slow growth, pain, intestinal gas and severe. Nutritional treatment can improve the growth, development and strength of patient. It involves a balanced diet with low fat and high protein which make strong the patient to resist aganist some infection (http//www.healthscout.com). It contain pancreatic enzymes to digest protein and fat and absorbance of various vitamins. Nutriational therapy also contain supplements of different vitamins. The other treatment for digestive problems is medications for the treatment of intestinal blockages (http//www.nhlbi.nih.gov/).GENE THERAPYGene therapy involve agit ate of DNA for therapeutic purpose. For the treatment of cystic fibrosis two approaches have been used. In the first approach, adenovirus was used as a vector, it has the epithelial cell lining. In this approach, adenovirus type-2 late promoter drives the CFTR gene. In the second approach, positively charged liposomes was used which can bind negatively charged DNA on its surface. These initial experiments have been used to change the electrical conductance of the nasal membrane. By these approaches a little correction of conductance abnormalities is possible. In the recent studies aerosol inhalers is used to saturate the upper part of the respiratory system. The reversal of the path physiology is possible if the correct form of CFTR gene is expressed.At present, retroviral-mediated gene transfer system is used for gene transfer for gene therapy of CF. Adenovirus is a suitable vector for gene transfer to the airway because it uses humans as a permissive host and it has a natural trop ism for the lung .Liposome-mediated DNA transfer system is also used for gene transfer in gene therapy. Liposome is positively charged interact with DNA which is negatively charged and form lipid-coated DNA complex Different positively charged liposomes used to transfer the CFTR including DOTAP, DMRIE and DOTMA-DOPE.Several new treatments are developed to treat the CF. In one case, the sodium-channel inhibitor amiloride is insert to the airways of the patients which inhibit sodium absorption. The other possible approach is to allow to bypass the CFTR chloride channel and regulate other chloride channel present in the membrane of airways. The most effective way to treat the CF is to insert a new and normal copy of CFTR gene into the airway of respiratory tract of CF patients. youthful ADVANCESIn recent years, various research works have improved the way to diagnose and treat cystic fibrosis. In the year 2006, it was published in the Science daily that certain scientists from Stanford University, USA were able to find out the basic defect causing CF. In which they had concluded that the airway blockage caused in CF was not caused due excessive fluid being reabsorbed within the glands but due to lack of fluid secretion from cystic fibrosis glands. (http//www.sciencedaily.com/releases/2006/03/060318232035.htm)In another research work done in the year 2008, certain scientist from USA were able to discover that a particular protein called CFTR were either missing or not present in the lungs of the CF patients which helps in fighting various bacteria like Pseudomonas aeruginosa when inhaled. Further studies are conducted to find the treatment through these proteins. (http//www.sciencedaily.com/releases/2008/09/080910210525.htm).In 2010, A team led by Professor Justin Hanes from John Hopkins university had researched on a mucus penetrating biodegradable nanoparticles which would help in spoken communication wide range of therapeutic molecules from small to various si ze of macromolecules to reduce the infection of lungs of the CF patients.In another research study done this year 2010, a team of researches were able to find out that a certain calcium- activated chloride channel were able to enable CF mucous cells to secrete normally which is required in the CFTR channel. So, it was concluded that drugs should be produces to enchance the ability of the calcium response which helps in activating the calcium activated chloride channels which are secreted in the CF cells. (http//www.sciencedaily.com/releases/2010/09/100917151848.htm)